A Novel Way To Stop The Development Of Fatal Huntington’s Disease Discovered By Researchers

Huntington’s disease characterized by death of brain cells mostly affects the middle-aged individuals in the age group of 30-50 years. It is an inherited disease that hampers muscular movement coordination and results in dementia. There is no cure for this deadly brain disease.

The study conducted by researchers at Johns Hopkins hospital may pave the way to find a potential solution for treating the Huntington’s disease.

Progression trend exhibited by Huntington’s Disease

The study was conducted on 30,000 individuals suffering from the disease in the US. Also, 200,000 individuals were analyzed who were under the risk of inheriting the disease.

For the purpose of the study mice and human stem cells were taken. As the experiment of mice may produce different results, the human tissue was analyzed.

The researchers of the study belong to departments at Hopkins, along with University of Florida and the University of California. Salts and proteins present in the brain cell need to move in and out of nucleus for proper functioning. In the case of Huntington’s patient, the genes clump together in the nucleus and move through nuclear pores causing blockage and death of brain cells and causing permanent brain damage.

The lead author of the study Grima said that we need to figure out the way to stop the blockage causing brain disorders. The research may help the patients to cure some forms of neurodegenerative disease for instance dementia.

Due to lack of muscle coordination, stability, brain disorders the life expectancy of an individual decreases almost by 20 years.

The treatments that are currently available just reduces the symptoms of the disease as there is no proper way to eradicate the disease completely.

Charbel Moussa, director of the Translational Neurotherapeutics Program from Georgetown University Medical Center said that cocktail of drugs will work to control symptoms and halt the disease progression.

The results of the study have been published in the journal Neuron.

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Micheal is a writer and editor who covers science, technology, and sustainability. He works at Prudour Network, where he is the Executive Editor, Grand Challenges. The job involves harnessing Prudour Network's vast expertise across many fields of science to address global challenges in health, sustainability, and other global challenges.